The Sepsis Text by Jean-Louis Vincent, Jean Carlet and Steven M. Opal
English | ISBN: 079237620X | 2002 | PDF | 869 pages | 19,2 mb
Sepsis, defined in its broadest sense as the syndrome evoked by the host response to infection, remains one of the most challenging problems in intensive care medicine. According to the Centers for Disease Control and Prevention (CDC), 500,000 cases of sepsis occur annually in the United States, an increase of almost 140 percent over the past decade.

Up to 14 percent of all patients admitted to intensive care units are affected by sepsis. When sepsis becomes severe and progresses to septic shock, multiple-organ dysfunction aggravates and prolongs the critical illness, necessitating a lengthy intensive care stay, and dramatically increases the risk of death. Although our understanding of the mechanisms underlying the evolution from infection to sepsis and multiple-organ failure has evolved substantially, mortality rates remain as high as 50 percent, depending on the definition of sepsis that is used. With the associated morbidity, the economic burden of sepsis also remains high. Novel therapies have been introduced, but many of the "magic bullets" have failed to improve the outcome.

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